What is regenerative medicine?
Regenerative medicine therapies, also sometimes called orthobiologics, use biological tissues found in the human body, such as blood, fat or bone marrow. In most cases, this type of biologic treatment is created using the patient’s own tissue to treat an injury. (This is called "autologous" regenerative medicine.) These therapies are generally safe for patients, since they are derived from the patient’s own cells.
What is orthopedic regenerative medicine used for?
Regenerative orthopedics may improve pain and discomfort of the musculoskeletal system and enhance the healing of orthopedic conditions, such as injuries of a tendon, ligament, bone, muscle, spinal disc, meniscus of the knee, cartilage or other musculoskeletal tissue. Most of these parts of the body have a relatively poor ability to heal on their own. The idea behind regenerative medicine is to help these tissues heal better. Orthobiologics can be used to treat degenerative conditions such as certain forms of arthritis, as well as sports injuries and traumas. Regenerative medicine may help some patients avoid orthopedic surgery completely.
Conditions commonly treated with regenerative medicine include:
• Osteoarthritis in Shoulder, Hip, Elbow, Knee, Ankle
• Tendonitis—Achilles, Elbow, Biceps, Hip
• Degenerative Disc Disease in the Spine
• Intervertebral disc tears in the Spine
• Fractures (broken bones) that are not healing correctly
• Cartilage injuries
• Muscle Strain injuries in athletes
• Labral tears (torn hip labrum or torn shoulder labrum)
• Ligament sprains or tears
• Partial Tendon Tears
• Nerve Inflammation
• Plantar Fasciitis in the foot
What is Orthobiologics?
Orthobiologics -- which you may hear referred to as biologics, cell-based therapy, regenerative medicine or stem cell therapy -- are derived from substances that naturally exist in the body. They may include cells, tissues, growth factors or components of the Physicians who specialize in orthobiologics are trained to access these naturally occurring substances in the human body and use them to treat a variety of orthopedic conditions in order to reduce pain and inflammation, stimulate healing or tissue regeneration, and ultimately improve musculoskeletal function.
Increased healing times of all body parts and organs
Cell-based therapies are composed of a variety of natural growth factors and cytokines which facilitate cell growth/differentiation and recruitment, modulate pain receptors and inflammatory mediators, and stimulate blood vessel growth, matrix synthesis, and tissue maturation/collagen synthesis. Basically, this means that when we talk about orthobiologics or cell therapy we are referring to transplantation of certain kinds of human cells to repair or heal damaged or inflamed tissue and/or cells. Depending on the type of orthobiologic treatment, there may be higher amounts of proinflammatory mediators or potent anti-inflammatory mediators. It’s important to understand that orthobiologic treatments don’t reverse arthritis or re-grow cartilage, but rather control symptoms and help naturally inhibit pain receptors.
Types of Cell Therapies
There are several different kinds of cell therapies that can be used to promote healing and reduce inflammation, including:
Platelet-rich plasma (PRP):
PRP is obtained by drawing a patient’s blood and spinning it in a centrifuge in order to concentrate the clot-forming platelets from the blood with or without white blood cells. The platelets are then injected directly into the affected area to speed up healing 3-5 times the concentration of growth factors in a routine draw of PRP.
Bone marrow aspirate concentrate (BMAC):
BMAC is the aspiration of a patient’s bone marrow, typically from the side of the pelvic bone. It is processed to extract a liquid rich in cells, growth factors, and a small percentage of stem cells. This liquid is injected directly into the affected area to speed up healing.
Adipose (fat) tissue can be suctioned from the abdomen and processed to remove fat cells. This leaves behind valuable anti-inflammatory mediators and growth factors along with a small percentage of the body’s stem cells, which is injected into the affected area.
This biologic therapy comes from a healthy donor source after C-section delivery. The amniotic fluid and membrane have hyaluronic acid and unique cells known to reduce inflammation and promote healing. These donor substances are injected into the affected area and are also a type of membrane used during surgeries.
Umbilical Cord-Derived Products:
This is connective tissue matrix of the human umbilical cord—“Wharton’s Jelly”. This matrix is filled with mesenchymal stromal cells, cytokines, growth factors , and hyaluronic acid. This is hypoimmunogenic. These products fit a specific criteria, minimally manipulated extra cellular matrix placental cells.
This type of orthobiologic treatment is the surgical transplantation of cartilage to a joint from another part of a joint, or from a donor source. The goal of this type of treatment is to replace an area of bad cartilage and underlying bone in an otherwise healthy joint in order to restore the natural smooth, healthy joint surface. For our intents and purposes, JFI BIO FOCUSES ON NONSURGICAL TREATMENT.
A Message From Dr. Brian Coleman, Our Chief Medical Officer
BE WARY: AVOID SUB-PAR CELL THERAPY TREATMENTS
I often am asked by patients how orthobiologics differ from highly-advertised treatments that claim to ‘regenerate’ or ‘heal quickly’ without surgery. These companies often market their treatments as cutting-edge stem cell therapy but don’t meet federal criteria.
The cell-based therapy of orthobiologics that we utilize are the same products available at what are often referred to as stem cell clinics that are frequently advertised. In the last few years there has been an explosion of these clinics that have emerged that are falsely advertising the typed of regenerative medicine offerings they provide. As previously stated, PRP and Bone Marrow Aspirate is taken from the body and reinjected in those parts of the body that are problematic for the patient. These are not stem cells! In fact, they only contain 1/1000 - 1/1,000,000 of cells that could be classified as stem cells and decrease as the patient ages! The vast majority of these so-called “Stem Cell Clinics” are utilizing products that do not fall under FDA approval under the current regenerative medicine guidelines.
Our Product Commitment
Orthobiologics through our company are regulated and backed by extensive orthopedic research. I am working along with research staff to remain at the forefront of basic science and ongoing clinical trial efforts to be leaders in the fields and optimize its use. My team oversees all aspects of current trends—federal regulations, billing and coding, to make sure that orthobiologic practices are properly regulated. We also ensure that patients are accurately informed about the therapies including when it comes to standardized cost, which isn’t guaranteed with other clinics. Our team is committed to providing patients extensively-researched and fairly price biological treatment options.
All Regenerative Medicine offerings by JFI Bio are FDA-approved for the category of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) regulated under section 361 of the Public Service (PHS) Act and 21 CFR Part 271. Our medical team has a 5-year history of applying our products and have experienced a 80—85% success rate in pain relief overall, essentially avoiding surgical procedures, post-surgical rehabilitation, and long-time off work or non-participation in recreational activities.
How to Get Started — Our Concierge Model
JFI Bio has conveniently created a Telemedicine portal for our interested patients to discuss all aspects of your problem(s) virtually. An in-person visit at our Boca Raton Location is an option as well. For a detailed visit (usually 30 minutes or less) either virtually or in the facility, you will need X-rays and a MRI of the involved body part(s) at one of our several diagnostic radiology partner facilities. You will not only get scheduled within 24-36 hours, a physician member of our team will contact you either virtually or in-person within 48 hours of your radiologic scans to discuss diagnosis and regenerative treatment options. For pricing options, click here.